Ontology highlight
ABSTRACT:
SUBMITTER: Meinel DM
PROVIDER: S-EPMC3828145 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Meinel Dominik M DM Burkert-Kautzsch Cornelia C Kieser Anja A O'Duibhir Eoghan E Siebert Matthias M Mayer Andreas A Cramer Patrick P Söding Johannes J Holstege Frank C P FC Sträßer Katja K
PLoS genetics 20131114 11
Messenger RNA (mRNA) synthesis and export are tightly linked, but the molecular mechanisms of this coupling are largely unknown. In Saccharomyces cerevisiae, the conserved TREX complex couples transcription to mRNA export and mediates mRNP formation. Here, we show that TREX is recruited to the transcription machinery by direct interaction of its subcomplex THO with the serine 2-serine 5 (S2/S5) diphosphorylated CTD of RNA polymerase II. S2 and/or tyrosine 1 (Y1) phosphorylation of the CTD is req ...[more]