Ontology highlight
ABSTRACT:
SUBMITTER: Schier AC
PROVIDER: S-EPMC7111264 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Schier Allison C AC Taatjes Dylan J DJ
Genes & development 20200401 7-8
RNA polymerase II (Pol II) transcribes all protein-coding genes and many noncoding RNAs in eukaryotic genomes. Although Pol II is a complex, 12-subunit enzyme, it lacks the ability to initiate transcription and cannot consistently transcribe through long DNA sequences. To execute these essential functions, an array of proteins and protein complexes interact with Pol II to regulate its activity. In this review, we detail the structure and mechanism of over a dozen factors that govern Pol II initi ...[more]