Ontology highlight
ABSTRACT:
SUBMITTER: Rusconi S
PROVIDER: S-EPMC3828227 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Rusconi Stefano S Vitiello Paola P Adorni Fulvio F Colella Elisa E Focà Emanuele E Capetti Amedeo A Meraviglia Paola P Abeli Clara C Bonora Stefano S D'Annunzio Marco M Di Biagio Antonio A Di Pietro Massimo M Butini Luca L Orofino Giancarlo G Colafigli Manuela M d'Ettorre Gabriella G Francisci Daniela D Parruti Giustino G Soria Alessandro A Buonomini Anna Rita AR Tommasi Chiara C Mosti Silvia S Bai Francesca F Di Nardo Stuppino Silvia S Morosi Manuela M Montano Marco M Tau Pamela P Merlini Esther E Marchetti Giulia G
PloS one 20131114 11
<h4>Background</h4>Immunological non-responders (INRs) lacked CD4 increase despite HIV-viremia suppression on HAART and had an increased risk of disease progression. We assessed immune reconstitution profile upon intensification with maraviroc in INRs.<h4>Methods</h4>We designed a multi-centric, randomized, parallel, open label, phase 4 superiority trial. We enrolled 97 patients on HAART with CD4+<200/µL and/or CD4+ recovery ≤ 25% and HIV-RNA<50 cp/mL. Patients were randomized 1:1 to HAART+marav ...[more]