Ontology highlight
ABSTRACT:
SUBMITTER: Senoo H
PROVIDER: S-EPMC3828593 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Senoo Hiroshi H Araki Tsuyoshi T Fukuzawa Masashi M Williams Jeffrey G JG
Journal of cell science 20130917 Pt 22
MrfA, a transcription factor that regulates Dictyostelium prestalk cell differentiation, is an orthologue of the metazoan myelin gene regulatory factor (MRF) proteins. We show that the MRFs contain a predicted transmembrane domain, suggesting that they are synthesised as membrane-tethered proteins that are then proteolytically released. We confirm this for MrfA but report a radically different mode of processing from that of paradigmatic tethered transcriptional regulators, which are cleaved wit ...[more]