Ontology highlight
ABSTRACT:
SUBMITTER: Xiang Y
PROVIDER: S-EPMC2692858 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Molecular cell 20090501 3
The tailed bacteriophage phi29 has 12 "appendages" (gene product 12, gp12) attached to its neck region that participate in host cell recognition and entry. In the cell, monomeric gp12 undergoes proteolytic processing that releases the C-terminal domain during assembly into trimers. We report here crystal structures of the protein before and after catalytic processing and show that the C-terminal domain of gp12 is an "autochaperone" that aids trimerization. We also show that autocleavage of the C ...[more]