Ontology highlight
ABSTRACT:
SUBMITTER: Heckman MG
PROVIDER: S-EPMC3829604 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Heckman Michael G MG Elbaz Alexis A Soto-Ortolaza Alexandra I AI Serie Daniel J DJ Aasly Jan O JO Annesi Grazia G Auburger Georg G Bacon Justin A JA Boczarska-Jedynak Magdalena M Bozi Maria M Brighina Laura L Chartier-Harlin Marie-Christine MC Dardiotis Efthimios E Destée Alain A Ferrarese Carlo C Ferraris Alessandro A Fiske Brian B Gispert Suzana S Hadjigeorgiou Georgios M GM Hattori Nobutaka N Ioannidis John P A JP Jasinska-Myga Barbara B Jeon Beom S BS Kim Yun Joong YJ Klein Christine C Kruger Rejko R Kyratzi Elli E Lin Chin-Hsien CH Lohmann Katja K Loriot Marie-Anne MA Lynch Timothy T Mellick George D GD Mutez Eugénie E Opala Grzegorz G Park Sung Sup SS Petrucci Simona S Quattrone Aldo A Sharma Manu M Silburn Peter A PA Sohn Young Ho YH Stefanis Leonidas L Tadic Vera V Tomiyama Hiroyuki H Uitti Ryan J RJ Valente Enza Maria EM Vassilatis Demetrios K DK Vilariño-Güell Carles C White Linda R LR Wirdefeldt Karin K Wszolek Zbigniew K ZK Wu Ruey-Meei RM Xiromerisiou Georgia G Maraganore Demetrius M DM Farrer Matthew J MJ Ross Owen A OA
Neurobiology of aging 20130817 1
The best validated susceptibility variants for Parkinson's disease are located in the α-synuclein (SNCA) and microtubule-associated protein tau (MAPT) genes. Recently, a protective p.N551K-R1398H-K1423K haplotype in the leucine-rich repeat kinase 2 (LRRK2) gene was identified, with p.R1398H appearing to be the most likely functional variant. To date, the consistency of the protective effect of LRRK2 p.R1398H across MAPT and SNCA variant genotypes has not been assessed. To address this, we examin ...[more]