Ontology highlight
ABSTRACT:
SUBMITTER: Henriques ST
PROVIDER: S-EPMC3829888 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Henriques Sónia Troeira ST Thorstholm Louise L Huang Yen-Hua YH Getz Jennifer A JA Daugherty Patrick S PS Craik David J DJ
PloS one 20131115 11
The inhibition of tyrosine kinases is a successful approach for the treatment of cancers and the discovery of kinase inhibitor drugs is the focus of numerous academic and pharmaceutical laboratories. With this goal in mind, several strategies have been developed to measure kinase activity and to screen novel tyrosine kinase inhibitors. Nevertheless, a general non-radioactive and inexpensive approach, easy to implement and adapt to a range of applications, is still missing. Herein, using Bcr-Abl ...[more]