Ontology highlight
ABSTRACT:
SUBMITTER: Ouyang Q
PROVIDER: S-EPMC3830955 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Ouyang Qing Q Lizarraga Sofia B SB Schmidt Michael M Yang Unikora U Gong Jingyi J Ellisor Debra D Kauer Julie A JA Morrow Eric M EM
Neuron 20130912 1
Neuronal arborization is regulated by cell-autonomous and nonautonomous mechanisms including endosomal signaling via BDNF/TrkB. The endosomal Na⁺/H⁺ exchanger 6 (NHE6) is mutated in a new autism-related disorder. NHE6 functions to permit proton leak from endosomes, yet the mechanisms causing disease are unknown. We demonstrate that loss of NHE6 results in overacidification of the endosomal compartment and attenuated TrkB signaling. Mouse brains with disrupted NHE6 display reduced axonal and dend ...[more]