Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles.
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ABSTRACT:
SUBMITTER: Fang RH
PROVIDER: S-EPMC3831007 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Publications
Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles.
Fang Ronnie H RH Hu Che-Ming J CM Chen Kevin N H KN Luk Brian T BT Carpenter Cody W CW Gao Weiwei W Li Shulin S Zhang Dong-Er DE Lu Weiyue W Zhang Liangfang L
Nanoscale 20130801 19
RBC membrane-cloaked polymeric nanoparticles represent an emerging nanocarrier platform with extended circulation in vivo. A lipid-insertion method is employed to functionalize these nanoparticles without the need for direct chemical conjugation. Insertion of both folate and the nucleolin-targeting aptamer AS1411 shows receptor-specific targeting against model cancer cell lines. ...[more]
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