Ontology highlight
ABSTRACT:
SUBMITTER: Goyne HE
PROVIDER: S-EPMC3831151 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Goyne Hannah E HE Cannon Martin J MJ
Frontiers in immunology 20131118
Clinical optimism for dendritic cell vaccination against ovarian cancer has been tempered by the knowledge that tumors avail themselves of multiple mechanisms of immune evasion, thus blunting the efficacy of therapeutic vaccination. Mechanisms of immune suppression include infiltration by regulatory T cells (Treg) and myeloid suppressor cell populations, expression of co-inhibitory receptors, and expression of indoleamine 2,3-dioxygenase (IDO). Expression of both B7-H1 and IDO are associated wit ...[more]