Ontology highlight
ABSTRACT:
SUBMITTER: Kalakonda S
PROVIDER: S-EPMC3831468 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Kalakonda Sudhakar S Nallar Shreeram C SC Jaber Sausan S Keay Susan K SK Rorke Ellen E Munivenkatappa Raghava R Lindner Daniel J DJ Fiskum Gary M GM Kalvakolanu Dhananjaya V DV
Proceedings of the National Academy of Sciences of the United States of America 20131021 45
Gene-associated with retinoid-interferon induced mortality-19 (GRIM-19), a STAT3-inhibitory protein, was isolated as a growth-suppressive gene product using a genome-wide expression knockdown screen. We and others have shown a loss of expression and occurrence of mutations in the GRIM-19 gene in a variety of primary human cancers, indicating its potential role as tumor suppressor. To help investigate its role in tumor development in vivo, we generated a genetically modified mouse in which Grim-1 ...[more]