Ontology highlight
ABSTRACT:
SUBMITTER: Amado IF
PROVIDER: S-EPMC3832933 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Amado Inês F IF Berges Julien J Luther Rita J RJ Mailhé Marie-Pierre MP Garcia Sylvie S Bandeira Antonio A Weaver Casey C Liston Adrian A Freitas Antonio A AA
The Journal of experimental medicine 20131101 12
Many species of bacteria use quorum sensing to sense the amount of secreted metabolites and to adapt their growth according to their population density. We asked whether similar mechanisms would operate in lymphocyte homeostasis. We investigated the regulation of the size of interleukin-2 (IL-2)-producing CD4(+) T cell (IL-2p) pool using different IL-2 reporter mice. We found that in the absence of either IL-2 or regulatory CD4(+) T (T reg) cells, the number of IL-2p cells increases. Administrat ...[more]