Ontology highlight
ABSTRACT:
SUBMITTER: Blanchette M
PROVIDER: S-EPMC383317 | biostudies-literature | 2004 Apr
REPOSITORIES: biostudies-literature
Blanchette Mathieu M Kent W James WJ Riemer Cathy C Elnitski Laura L Smit Arian F A AF Roskin Krishna M KM Baertsch Robert R Rosenbloom Kate K Clawson Hiram H Green Eric D ED Haussler David D Miller Webb W
Genome research 20040401 4
We define a "threaded blockset," which is a novel generalization of the classic notion of a multiple alignment. A new computer program called TBA (for "threaded blockset aligner") builds a threaded blockset under the assumption that all matching segments occur in the same order and orientation in the given sequences; inversions and duplications are not addressed. TBA is designed to be appropriate for aligning many, but by no means all, megabase-sized regions of multiple mammalian genomes. The ou ...[more]