Ontology highlight
ABSTRACT:
SUBMITTER: Guo CJ
PROVIDER: S-EPMC3833251 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Guo Chun-Jun CJ Knox Benjamin P BP Sanchez James F JF Chiang Yi-Ming YM Bruno Kenneth S KS Wang Clay C C CC
Organic letters 20130710 14
Nonribosomal peptides (NRPs) are natural products biosynthesized by NRP synthetases. A kusA-, pyrG- mutant strain of Aspergillus terreus NIH 2624 was developed that greatly facilitated the gene targeting efficiency in this organism. Application of this tool allowed us to link four major types of NRP-related secondary metabolites to their responsible genes in A. terreus. In addition, an NRP affecting melanin synthesis was also identified in this species. ...[more]