Ontology highlight
ABSTRACT:
SUBMITTER: Glauber KM
PROVIDER: S-EPMC3833435 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Glauber Kristine M KM Dana Catherine E CE Park Steve S SS Colby David A DA Noro Yukihiko Y Fujisawa Toshitaka T Chamberlin A Richard AR Steele Robert E RE
Development (Cambridge, England) 20131201 23
Developmental processes such as morphogenesis, patterning and differentiation are continuously active in the adult Hydra polyp. We carried out a small molecule screen to identify compounds that affect patterning in Hydra. We identified a novel molecule, DAC-2-25, that causes a homeotic transformation of body column into tentacle zone. This transformation occurs in a progressive and polar fashion, beginning at the oral end of the animal. We have identified several strains that respond to DAC-2-25 ...[more]