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Coregulation of HIV-1 dependency factors in individuals heterozygous to the CCR5-delta32 deletion.


ABSTRACT:

Background

CCR5-delta32 heterozygous individuals are susceptible to HIV-1. However, it is not clear if there is a relevant protective effect against transmission and a beneficial effect in terms of HIV progression which cannot be attributed to CCR5 surface density alone. Therefore we investigated HIV-1 dependency factors (HDF) which might be differently regulated in CCR5 wild type (WT) and CCR5-delta32 heterozygous individuals.

Methods

We examined CD34+ hematopoietic progenitor cells derived from bone marrow samples from 19 healthy volunteers, 12 individuals with CCR5 WT and 7 with heterozygous CCR5-delta32 deletion. Samples were analyzed using a global gene expression oligonucleotide microarray (HG-U133plus 2.0, Affymetrix Inc.).

Results

A total of 205 genes were found with altered expression (3fold difference, present call rate of 75%, p?ConclusionThe CCR5-delta32 deletion is associated with other HDFs in HIV-1 pathogenesis as a possible explanation for beneficial effects regarding the deletion leading to a variant expression profile in heterozygous carriers of this mutation.

SUBMITTER: Hutter G 

PROVIDER: S-EPMC3834523 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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Publications

Coregulation of HIV-1 dependency factors in individuals heterozygous to the CCR5-delta32 deletion.

Hütter Gero G   Blüthgen Christian C   Neumann Martin M   Reinwald Mark M   Nowak Daniel D   Klüter Harald H  

AIDS research and therapy 20131118 1


<h4>Background</h4>CCR5-delta32 heterozygous individuals are susceptible to HIV-1. However, it is not clear if there is a relevant protective effect against transmission and a beneficial effect in terms of HIV progression which cannot be attributed to CCR5 surface density alone. Therefore we investigated HIV-1 dependency factors (HDF) which might be differently regulated in CCR5 wild type (WT) and CCR5-delta32 heterozygous individuals.<h4>Methods</h4>We examined CD34+ hematopoietic progenitor ce  ...[more]

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