Ontology highlight
ABSTRACT:
SUBMITTER: Mythreye K
PROVIDER: S-EPMC3835656 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Mythreye K K Knelson E H EH Gatza C E CE Gatza M L ML Blobe G C GC
Oncogene 20120507 11
The type III TGF-β receptor (TβRIII) is a ubiquitous co-receptor for TGF-β superfamily ligands with roles in suppressing cancer progression, in part through suppressing cell motility. Here we demonstrate that TβRIII promotes epithelial cell adhesion to fibronectin in a β-arrestin2 dependent and TGF-β/BMP independent manner by complexing with active integrin α5β1, and mediating β-arrestin2-dependent α5β1 internalization and trafficking to nascent focal adhesions. TβRIII-mediated integrin α5β1 tra ...[more]