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DNA translocation through hydrophilic nanopore in hexagonal boron nitride.


ABSTRACT: Ultra-thin solid-state nanopore with good wetting property is strongly desired to achieve high spatial resolution for DNA sequencing applications. Atomic thick hexagonal boron nitride (h-BN) layer provides a promising two-dimensional material for fabricating solid-state nanopores. Due to its good oxidation resistance, the hydrophilicity of h-BN nanopore device can be significantly improved by UV-Ozone treatment. The contact angle of a KCl-TE droplet on h-BN layer can be reduced from 57° to 26° after the treatment. Abundant DNA translocation events have been observed in such devices, and strong DNA-nanopore interaction has been revealed in pores smaller than 10 nm in diameter. The 1/f noise level is closely related to the area of suspended h-BN layer, and it is significantly reduced in smaller supporting window. The demonstrated performance in h-BN nanopore paves the way towards base discrimination in a single DNA molecule.

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC3836030 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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DNA translocation through hydrophilic nanopore in hexagonal boron nitride.

Zhou Zhi Z   Hu Ying Y   Wang Hao H   Xu Zhi Z   Wang Wenlong W   Bai Xuedong X   Shan Xinyan X   Lu Xinghua X  

Scientific reports 20131121


Ultra-thin solid-state nanopore with good wetting property is strongly desired to achieve high spatial resolution for DNA sequencing applications. Atomic thick hexagonal boron nitride (h-BN) layer provides a promising two-dimensional material for fabricating solid-state nanopores. Due to its good oxidation resistance, the hydrophilicity of h-BN nanopore device can be significantly improved by UV-Ozone treatment. The contact angle of a KCl-TE droplet on h-BN layer can be reduced from 57° to 26° a  ...[more]

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