Ontology highlight
ABSTRACT:
SUBMITTER: Saijilafu
PROVIDER: S-EPMC3836055 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Saijilafu Hur Eun-Mi EM Liu Chang-Mei CM Jiao Zhongxian Z Xu Wen-Lin WL Zhou Feng-Quan FQ
Nature communications 20130101
In contrast to neurons in the central nervous system, mature neurons in the mammalian peripheral nervous system (PNS) can regenerate axons after injury, in part, by enhancing intrinsic growth competence. However, the signalling pathways that enhance the growth potential and induce spontaneous axon regeneration remain poorly understood. Here we reveal that phosphatidylinositol 3-kinase (PI3K) signalling is activated in response to peripheral axotomy and that PI3K pathway is required for sensory a ...[more]