Ontology highlight
ABSTRACT:
SUBMITTER: Zhang BY
PROVIDER: S-EPMC3916952 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Zhang Bo-Yin BY Saijilafu Liu Chang-Mei CM Wang Rui-Ying RY Zhu Qingsan Q Jiao Zhongxian Z Zhou Feng-Quan FQ
Biochemical and biophysical research communications 20131212 2
Inactivation of glycogen synthase kinase 3 (GSK3) has been shown to mediate axon growth during development and regeneration. Phosphorylation of GSK3 by the kinase Akt is well known to be the major mechanism by which GSK3 is inactivated. However, whether such regulatory mechanism of GSK3 inactivation is used in neurons to control axon growth has not been directly studied. Here by using GSK3 mutant mice, in which GSK3 is insensitive to Akt-mediated inactivation, we show that sensory axons regenera ...[more]