Ontology highlight
ABSTRACT:
SUBMITTER: Hermann C
PROVIDER: S-EPMC3836178 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Hermann Clemens C Strittmatter Lisa M LM Deane Janet E JE Boyle Louise H LH
Journal of immunology (Baltimore, Md. : 1950) 20131025 11
The loading of peptide Ags onto MHC class I molecules is a highly controlled process in which the MHC class I-dedicated chaperone tapasin is a key player. We recently identified a tapasin-related molecule, TAPBPR, as an additional component in the MHC class I Ag-presentation pathway. In this study, we show that the amino acid residues important for tapasin to interact with MHC class I are highly conserved on TAPBPR. We identify specific residues in the N-terminal and C-terminal domains of TAPBPR ...[more]