Ontology highlight
ABSTRACT:
SUBMITTER: Morozov GI
PROVIDER: S-EPMC4776512 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Morozov Giora I GI Zhao Huaying H Mage Michael G MG Boyd Lisa F LF Jiang Jiansheng J Dolan Michael A MA Venna Ramesh R Norcross Michael A MA McMurtrey Curtis P CP Hildebrand William W Schuck Peter P Natarajan Kannan K Margulies David H DH
Proceedings of the National Academy of Sciences of the United States of America 20160211 8
Peptide loading of major histocompatibility complex class I (MHC-I) molecules is central to antigen presentation, self-tolerance, and CD8(+) T-cell activation. TAP binding protein, related (TAPBPR), a widely expressed tapasin homolog, is not part of the classical MHC-I peptide-loading complex (PLC). Using recombinant MHC-I molecules, we show that TAPBPR binds HLA-A*02:01 and several other MHC-I molecules that are either peptide-free or loaded with low-affinity peptides. Fluorescence polarization ...[more]