Ontology highlight
ABSTRACT:
SUBMITTER: Menni C
PROVIDER: S-EPMC3837024 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Menni Cristina C Fauman Eric E Erte Idil I Perry John R B JR Kastenmüller Gabi G Shin So-Youn SY Petersen Ann-Kristin AK Hyde Craig C Psatha Maria M Ward Kirsten J KJ Yuan Wei W Milburn Mike M Palmer Colin N A CN Frayling Timothy M TM Trimmer Jeff J Bell Jordana T JT Gieger Christian C Mohney Rob P RP Brosnan Mary Julia MJ Suhre Karsten K Soranzo Nicole N Spector Tim D TD
Diabetes 20130724 12
Using a nontargeted metabolomics approach of 447 fasting plasma metabolites, we searched for novel molecular markers that arise before and after hyperglycemia in a large population-based cohort of 2,204 females (115 type 2 diabetic [T2D] case subjects, 192 individuals with impaired fasting glucose [IFG], and 1,897 control subjects) from TwinsUK. Forty-two metabolites from three major fuel sources (carbohydrates, lipids, and proteins) were found to significantly correlate with T2D after adjusting ...[more]