Ontology highlight
ABSTRACT:
SUBMITTER: Acosta L
PROVIDER: S-EPMC3837061 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Acosta Lourdes L Hmadcha Abdelkrim A Escacena Natalia N Pérez-Camacho Inmaculada I de la Cuesta Antonio A Ruiz-Salmeron Rafael R Gauthier Benoit R BR Soria Bernat B
Diabetes 20130916 12
Stem cells have been successfully used for the treatment of critical limb ischemia (CLI). We conducted a clinical trial to determine the feasibility of using autologous adipose-derived mesenchymal stromal cells (AdMSCs) for the treatment of CLI. Unexpectedly, two diabetic patients developed peripheral microthrombosis. This adverse effect, which contrasts with the reported antithrombotic properties of MSCs, may stem from the diabetic environment that alters the fibrinolytic activity of AdMSCs, th ...[more]