Ontology highlight
ABSTRACT:
SUBMITTER: Sikora-Wohlfeld W
PROVIDER: S-EPMC3837635 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Sikora-Wohlfeld Weronika W Ackermann Marit M Christodoulou Eleni G EG Singaravelu Kalaimathy K Beyer Andreas A
PLoS computational biology 20131121 11
Chromatin immunoprecipitation coupled with deep sequencing (ChIP-seq) has great potential for elucidating transcriptional networks, by measuring genome-wide binding of transcription factors (TFs) at high resolution. Despite the precision of these experiments, identification of genes directly regulated by a TF (target genes) is not trivial. Numerous target gene scoring methods have been used in the past. However, their suitability for the task and their performance remain unclear, because a thoro ...[more]