Ontology highlight
ABSTRACT:
SUBMITTER: Au-Yeung HY
PROVIDER: S-EPMC3838104 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20130924 40
Iron is an essential metal for living organisms, but misregulation of its homeostasis at the cellular level can trigger detrimental oxidative and/or nitrosative stress and damage events. Motivated to help study the physiological and pathological consequences of biological iron regulation, we now report a reaction-based strategy for monitoring labile Fe(2+) pools in aqueous solution and living cells. Iron Probe 1 (IP1) exploits a bioinspired, iron-mediated oxidative C-O bond cleavage reaction to ...[more]