A single amino acid mutation in the envelope cytoplasmic tail restores the ability of an attenuated simian immunodeficiency virus mutant to deplete mucosal CD4+ T cells.
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ABSTRACT:
SUBMITTER: Breed MW
PROVIDER: S-EPMC3838135 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
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A single amino acid mutation in the envelope cytoplasmic tail restores the ability of an attenuated simian immunodeficiency virus mutant to deplete mucosal CD4+ T cells.
Breed Matthew W MW Jordan Andrea P O AP Aye Pyone P PP Sugimoto Chie C Alvarez Xavier X Kuroda Marcelo J MJ Pahar Bapi B Keele Brandon F BF Hoxie James A JA Lackner Andrew A AA
Journal of virology 20130911 23
Disruption of the conserved motif GYxxØ in the simian immunodeficiency virus (SIV) SIVmac239 envelope (Env) cytoplasmic tail resulted in a virus (ΔGY) that exhibited a high plasma peak but uniquely failed to acutely deplete mucosal CD4(+) T cells. Here, we show that ΔGY containing a flanking S727P mutation that was acquired in ΔGY-infected macaques reacquired the ability to rapidly deplete CD4(+) T cells in lamina propria. This suggests that the GYxxØ motif and S727P each contribute to SIV's tar ...[more]
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