Nonhuman transferrin receptor 1 is an efficient cell entry receptor for Ocozocoautla de Espinosa virus.
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ABSTRACT:
SUBMITTER: Cai Y
PROVIDER: S-EPMC3838296 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Publications
Nonhuman transferrin receptor 1 is an efficient cell entry receptor for Ocozocoautla de Espinosa virus.
Caì Yíngyún Y Yú Shuiqìng S Mazur Steven S Dong Lián L Janosko Krisztina K Zhang Téngfei T Müller Marcel A MA Hensley Lisa E LE Bavari Sina S Jahrling Peter B PB Radoshitzky Sheli R SR Kuhn Jens H JH
Journal of virology 20131009 24
Ocozocoautla de Espinosa virus (OCEV) is a novel, uncultured arenavirus. We found that the OCEV glycoprotein mediates entry into grivet and bat cells through transferrin receptor 1 (TfR1) binding but that OCEV glycoprotein precursor (GPC)-pseudotyped retroviruses poorly entered 53 human cancer cell lines. Interestingly, OCEV and Tacaribe virus could use bat, but not human, TfR1. Replacing three human TfR1 amino acids with their bat ortholog counterparts transformed human TfR1 into an efficient O ...[more]
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