Ontology highlight
ABSTRACT:
SUBMITTER: Banaszynski LA
PROVIDER: S-EPMC3838450 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Cell 20130901 1
Polycomb repressive complex 2 (PRC2) regulates gene expression during lineage specification through trimethylation of lysine 27 on histone H3 (H3K27me3). In Drosophila, polycomb binding sites are dynamic chromatin regions enriched with the histone variant H3.3. Here, we show that, in mouse embryonic stem cells (ESCs), H3.3 is required for proper establishment of H3K27me3 at the promoters of developmentally regulated genes. Upon H3.3 depletion, these promoters show reduced nucleosome turnover mea ...[more]