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Bisphosphonates target B cells to enhance humoral immune responses.

ABSTRACT: Bisphosphonates are a class of drugs that are widely used to inhibit loss of bone mass in patients. We show here that the administration of clinically relevant doses of bisphosphonates in mice increases antibody responses to live and inactive viruses, proteins, haptens, and existing commercial vaccine formulations. Bisphosphonates exert this adjuvant-like activity in the absence of CD4(+) and ?? T cells, neutrophils, or dendritic cells, and their effect does not rely on local macrophage depletion, Toll-like receptor signaling, or the inflammasome. Rather, bisphosphonates target directly B cells and enhance B cell expansion and antibody production upon antigen encounter. These data establish bisphosphonates as an additional class of adjuvants that boost humoral immune responses.

SUBMITTER: Tonti E

PROVIDER: S-EPMC3838640 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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Bisphosphonates target B cells to enhance humoral immune responses.

Tonti Elena E Jiménez de Oya Nereida N Galliverti Gabriele G Moseman E Ashley EA Di Lucia Pietro P Amabile Angelo A Sammicheli Stefano S De Giovanni Marco M Sironi Laura L Chevrier Nicolas N Sitia Giovanni G Gennari Luigi L Guidotti Luca G LG von Andrian Ulrich H UH Iannacone Matteo M

Cell reports 20131010 2

Bisphosphonates are a class of drugs that are widely used to inhibit loss of bone mass in patients. We show here that the administration of clinically relevant doses of bisphosphonates in mice increases antibody responses to live and inactive viruses, proteins, haptens, and existing commercial vaccine formulations. Bisphosphonates exert this adjuvant-like activity in the absence of CD4(+) and γδ T cells, neutrophils, or dendritic cells, and their effect does not rely on local macrophage depletio ...[more]

PMID: 24120862

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