Drosophila Dachsous and Fat polarize actin-based protrusions over a restricted domain of the embryonic denticle field.

ABSTRACT: Atypical cadherins Dachsous (Ds) and Fat coordinate the establishment of planar polarity, essential for the patterning of complex tissues and organs. The precise mechanisms by which this system acts, particularly in cases where Ds and Fat act independently of the 'core' frizzled system, are still the subject of investigation. Examining the deployment of the Ds-Fat system in different tissues of the model organism Drosophila, has provided insights into the general mechanisms by which polarity is established and propagated to coordinate outcomes across a field of cells. The Drosophila embryonic epidermis provides a simple model epithelia where the establishment of polarity can be observed from start to finish, and in the absence of proliferation, over a fixed number of cells. Using the asymm

SUBMITTER: Lawlor KT 

PROVIDER: S-EPMC3839345 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature