Ontology highlight
ABSTRACT:
SUBMITTER: Jones KA
PROVIDER: S-EPMC3839535 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Nature chemical biology 20130825 10
Melanopsin, expressed in a subset of retinal ganglion cells, mediates behavioral adaptation to ambient light and other non-image-forming photic responses. This has raised the possibility that pharmacological manipulation of melanopsin can modulate several central nervous system responses, including photophobia, sleep, circadian rhythms and neuroendocrine function. Here we describe the identification of a potent synthetic melanopsin antagonist with in vivo activity. New sulfonamide compounds inhi ...[more]