Ontology highlight
ABSTRACT:
SUBMITTER: Holland PR
PROVIDER: S-EPMC5935646 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Holland Philip R PR Goadsby Peter J PJ
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20180401 2
Migraine is a highly prevalent, severe, and disabling neurological condition with a significant unmet need for effective acute therapies. Patients (~50%) are dissatisfied with their currently available therapies. Calcitonin gene-related peptide (CGRP) has emerged as a key neuropeptide involved in the pathophysiology of migraines. As reviewed in this manuscript, a number of small molecule antagonists of the CGRP receptor have been developed for migraine therapy. Incredibly, the majority of the cl ...[more]