Ontology highlight
ABSTRACT:
SUBMITTER: Yao Y
PROVIDER: S-EPMC3839731 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Yao Yucheng Y Yao Jiayi J Radparvar Melina M Blazquez-Medela Ana M AM Guihard Pierre J PJ Jumabay Medet M Boström Kristina I KI
Proceedings of the National Academy of Sciences of the United States of America 20131104 47
Cerebral arteriovenous malformations (AVMs) are common vascular malformations, which may result in hemorrhagic strokes and neurological deficits. Bone morphogenetic protein (BMP) and Notch signaling are both involved in the development of cerebral AVMs, but the cross-talk between the two signaling pathways is poorly understood. Here, we show that deficiency of matrix Gla protein (MGP), a BMP inhibitor, causes induction of Notch ligands, dysregulation of endothelial differentiation, and the devel ...[more]