Ontology highlight
ABSTRACT:
SUBMITTER: Shin JW
PROVIDER: S-EPMC3839750 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Shin Jae-Won JW Spinler Kyle R KR Swift Joe J Chasis Joel A JA Mohandas Narla N Discher Dennis E DE
Proceedings of the National Academy of Sciences of the United States of America 20131104 47
Hematopoietic stem and progenitor cells, as well as nucleated erythroblasts and megakaryocytes, reside preferentially in adult marrow microenvironments whereas other blood cells readily cross the endothelial barrier into the circulation. Because the nucleus is the largest organelle in blood cells, we hypothesized that (i) cell sorting across microporous barriers is regulated by nuclear deformability as controlled by lamin-A and -B, and (ii) lamin levels directly modulate hematopoietic programs. ...[more]