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Dendritic Cell Lineage Potential in Human Early Hematopoietic Progenitors.

ABSTRACT: Conventional dendritic cells (cDCs) are thought to descend from a DC precursor downstream of the common myeloid progenitor (CMP). However, a mouse lymphoid-primed multipotent progenitor has been shown to generate cDCs following a DC-specific developmental pathway independent of monocyte and granulocyte poiesis. Similarly, here we show that, in humans, a large fraction of multipotent lymphoid early progenitors (MLPs) gives rise to cDCs, in particular the subset known as cDC1, identified by co-expression of DNGR-1 (CLEC9A) and CD141 (BDCA-3). Single-cell analysis indicates that over one-third of MLPs have the potential to efficiently generate cDCs. cDC1s generated from CMPs or MLPs do not exhibit differences in transcriptome or phenotype. These results demonstrate an early imprinting of the cDC lineage in human hematopoiesis and highlight the plasticity of developmental pathways giving rise to human DCs.

SUBMITTER: Helft J

PROVIDER: S-EPMC5529209 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Dendritic Cell Lineage Potential in Human Early Hematopoietic Progenitors.

Helft Julie J Anjos-Afonso Fernando F van der Veen Annemarthe G AG Chakravarty Probir P Bonnet Dominique D Reis e Sousa Caetano C

Cell reports 20170701 3

Conventional dendritic cells (cDCs) are thought to descend from a DC precursor downstream of the common myeloid progenitor (CMP). However, a mouse lymphoid-primed multipotent progenitor has been shown to generate cDCs following a DC-specific developmental pathway independent of monocyte and granulocyte poiesis. Similarly, here we show that, in humans, a large fraction of multipotent lymphoid early progenitors (MLPs) gives rise to cDCs, in particular the subset known as cDC1, identified by co-exp ...[more]

PMID: 28723558

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