Ontology highlight
ABSTRACT:
SUBMITTER: Smith TE
PROVIDER: S-EPMC3839781 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Smith Thomas E TE Hong Weili W Zachariah Malcolm M MM Harper Mary Kay MK Matainaho Teatulohi K TK Van Wagoner Ryan M RM Ireland Chris M CM Vershinin Michael M
Proceedings of the National Academy of Sciences of the United States of America 20131104 47
Two merotriterpenoid hydroquinone sulfates designated adociasulfate-13 (1) and adociasulfate-14 (2) were purified from Cladocroce aculeata (Chalinidae) along with adociasulfate-8. All three compounds were found to inhibit microtubule-stimulated ATPase activity of kinesin at 15 µM by blocking both the binding of microtubules and the processive motion of kinesin along microtubules. These findings directly show that substitution of the 5'-sulfate in 1 for a glycolic acid moiety in 2 maintains kines ...[more]