Ontology highlight
ABSTRACT:
SUBMITTER: Behjati S
PROVIDER: S-EPMC3839851 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Behjati Sam S Tarpey Patrick S PS Presneau Nadège N Scheipl Susanne S Pillay Nischalan N Van Loo Peter P Wedge David C DC Cooke Susanna L SL Gundem Gunes G Davies Helen H Nik-Zainal Serena S Martin Sancha S McLaren Stuart S Goodie Victoria V Robinson Ben B Butler Adam A Teague Jon W JW Halai Dina D Khatri Bhavisha B Myklebost Ola O Baumhoer Daniel D Jundt Gernot G Hamoudi Rifat R Tirabosco Roberto R Amary M Fernanda MF Futreal P Andrew PA Stratton Michael R MR Campbell Peter J PJ Flanagan Adrienne M AM
Nature genetics 20131027 12
It is recognized that some mutated cancer genes contribute to the development of many cancer types, whereas others are cancer type specific. For genes that are mutated in multiple cancer classes, mutations are usually similar in the different affected cancer types. Here, however, we report exquisite tumor type specificity for different histone H3.3 driver alterations. In 73 of 77 cases of chondroblastoma (95%), we found p.Lys36Met alterations predominantly encoded in H3F3B, which is one of two g ...[more]