Ontology highlight
ABSTRACT:
SUBMITTER: Wood NT
PROVIDER: S-EPMC3841175 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Wood Natasha T NT Fadda Elisa E Davis Robert R Grant Oliver C OC Martin Joanne C JC Woods Robert J RJ Travers Simon A SA
PloS one 20131126 11
N-linked glycans attached to specific amino acids of the gp120 envelope trimer of a HIV virion can modulate the binding affinity of gp120 to CD4, influence coreceptor tropism, and play an important role in neutralising antibody responses. Because of the challenges associated with crystallising fully glycosylated proteins, most structural investigations have focused on describing the features of a non-glycosylated HIV-1 gp120 protein. Here, we use a computational approach to determine the influen ...[more]