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A cure for AIDS: a matter of timing?

ABSTRACT: Despite the huge clinical success of antiretroviral therapy, several factors such as side effects, requirement of life-long adherence, high cost, incomplete access to therapies and development of drug resistance make the quest for an ultimate cure of HIV/AIDS a worldwide priority of biomedical research. In this respect, several sterilizing or functional cures have been reported in the last years in both non-human primates and humans. This review provides a summary of the main results achieved so far, outlining their strengths as well as their limitations. A synthetic interpretation of these results could be pivotal in order to develop an effective and widely available cure.

SUBMITTER: Shytaj IL

PROVIDER: S-EPMC3842794 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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A cure for AIDS: a matter of timing?

Shytaj Iart Luca IL Savarino Andrea A

Retrovirology 20131122

Despite the huge clinical success of antiretroviral therapy, several factors such as side effects, requirement of life-long adherence, high cost, incomplete access to therapies and development of drug resistance make the quest for an ultimate cure of HIV/AIDS a worldwide priority of biomedical research. In this respect, several sterilizing or functional cures have been reported in the last years in both non-human primates and humans. This review provides a summary of the main results achieved so ...[more]

PMID: 24267982

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