Ontology highlight
ABSTRACT:
SUBMITTER: Blattler A
PROVIDER: S-EPMC3843044 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20131022 48
DNA methylation, which occurs predominantly at CpG dinucleotides, is a potent epigenetic repressor of transcription. Because DNA methylation is reversible, there is much interest in understanding the mechanisms by which it can be regulated by DNA-binding transcription factors. We discuss several models that, by incorporating sequence motifs, CpG density, and methylation levels, attempt to link the binding of a transcription factor with the acquisition or loss of DNA methylation at promoters and ...[more]