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Cross-talk between site-specific transcription factors and DNA methylation states.

ABSTRACT: DNA methylation, which occurs predominantly at CpG dinucleotides, is a potent epigenetic repressor of transcription. Because DNA methylation is reversible, there is much interest in understanding the mechanisms by which it can be regulated by DNA-binding transcription factors. We discuss several models that, by incorporating sequence motifs, CpG density, and methylation levels, attempt to link the binding of a transcription factor with the acquisition or loss of DNA methylation at promoters and distal regulatory elements. Additional in vivo genome-wide characterization of transcription factor binding patterns and high-resolution DNA methylation analyses are clearly required for stronger support of each model.

SUBMITTER: Blattler A

PROVIDER: S-EPMC3843044 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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Cross-talk between site-specific transcription factors and DNA methylation states.

Blattler Adam A Farnham Peggy J PJ

The Journal of biological chemistry 20131022 48

DNA methylation, which occurs predominantly at CpG dinucleotides, is a potent epigenetic repressor of transcription. Because DNA methylation is reversible, there is much interest in understanding the mechanisms by which it can be regulated by DNA-binding transcription factors. We discuss several models that, by incorporating sequence motifs, CpG density, and methylation levels, attempt to link the binding of a transcription factor with the acquisition or loss of DNA methylation at promoters and ...[more]

PMID: 24151070

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