Ontology highlight
ABSTRACT:
SUBMITTER: Hobbs CM
PROVIDER: S-EPMC3843237 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Hobbs Catherine M CM Manning Harriet H Bennett Cavan C Vasquez Louella L Severin Sonia S Brain Lauren L Mazharian Alexandra A Guerrero Jose A JA Li Juan J Soranzo Nicole N Green Anthony R AR Watson Steve P SP Ghevaert Cedric C
Blood 20131001 23
The principal morbidity and mortality in patients with essential thrombocythemia (ET) and polycythemia rubra vera (PV) stems from thrombotic events. Most patients with ET/PV harbor a JAK2V617F mutation, but its role in the thrombotic diathesis remains obscure. Platelet function studies in patients are difficult to interpret because of interindividual heterogeneity, reflecting variations in the proportion of platelets derived from the malignant clone, differences in the presence of additional mut ...[more]