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The dataset for protein-RNA binding affinity.


ABSTRACT: We have developed a non-redundant protein-RNA binding benchmark dataset derived from the available protein-RNA structures in the Protein Database Bank. It consists of 73 complexes with measured binding affinity. The experimental conditions (pH and temperature) for binding affinity measurements are also listed in our dataset. This binding affinity dataset can be used to compare and develop protein-RNA scoring functions. The predicted binding free energy of the 73 complexes from three available scoring functions for protein-RNA docking has a low correlation with the binding Gibbs free energy calculated from Kd.

SUBMITTER: Yang X 

PROVIDER: S-EPMC3843634 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature

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The dataset for protein-RNA binding affinity.

Yang Xiufeng X   Li Haotian H   Huang Yangyu Y   Liu Shiyong S  

Protein science : a publication of the Protein Society 20131201 12


We have developed a non-redundant protein-RNA binding benchmark dataset derived from the available protein-RNA structures in the Protein Database Bank. It consists of 73 complexes with measured binding affinity. The experimental conditions (pH and temperature) for binding affinity measurements are also listed in our dataset. This binding affinity dataset can be used to compare and develop protein-RNA scoring functions. The predicted binding free energy of the 73 complexes from three available sc  ...[more]

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