Ontology highlight
ABSTRACT:
SUBMITTER: Muller KH
PROVIDER: S-EPMC3843813 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Müller Karin H KH Motskin Michael M Philpott Alistair J AJ Routh Alexander F AF Shanahan Catherine M CM Duer Melinda J MJ Skepper Jeremy N JN
Biomaterials 20131030 3
Agglomeration dramatically affects many aspects of nanoparticle-cell interactions. Here we show that hydroxyapatite nanoparticles formed large agglomerates in biological medium resulting in extensive particle uptake and dose-dependent cytotoxicity in human macrophages. Particle citration and/or the addition of the dispersant Darvan 7 dramatically reduced mean agglomerate sizes, the amount of particle uptake and concomitantly cytotoxicity. More surprisingly, agglomeration governed the mode of par ...[more]