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Pregnancy-specific glycoprotein 1 (PSG1) activates TGF-? and prevents dextran sodium sulfate (DSS)-induced colitis in mice.

ABSTRACT: Transforming growth factor-?s (TGF-?s) are secreted from cells as latent complexes and the activity of TGF-?s is controlled predominantly through activation of these complexes. Tolerance to the fetal allograft is essential for pregnancy success; TGF-?1 and TGF-?2 play important roles in regulating these processes. Pregnancy-specific ?-glycoproteins (PSGs) are present in the maternal circulation at a high concentration throughout pregnancy and have been proposed to have anti-inflammatory functions. We found that recombinant and native PSG1 activate TGF-?1 and TGF-?2 in vitro. Consistent with these findings, administration of PSG1 protected mice from dextran sodium sulfate (DSS)-induced colitis, reduced the secretion of pro-inflammatory cytokines, and increased the number of T regulatory cells. The PSG1-mediated protection was greatly inhibited by the coadministration of neutralizing anti-TGF-? antibody. Our results indicate that proteins secreted by the placenta directly contribute to the generation of active TGF-? and identify PSG1 as one of the few known biological activators of TGF-?2.

SUBMITTER: Blois SM

PROVIDER: S-EPMC3844031 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

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Pregnancy-specific glycoprotein 1 (PSG1) activates TGF-β and prevents dextran sodium sulfate (DSS)-induced colitis in mice.

Blois S M SM Sulkowski G G Tirado-González I I Warren J J Freitag N N Klapp B F BF Rifkin D D Fuss I I Strober W W Dveksler G S GS

Mucosal immunology 20130814 2

Transforming growth factor-βs (TGF-βs) are secreted from cells as latent complexes and the activity of TGF-βs is controlled predominantly through activation of these complexes. Tolerance to the fetal allograft is essential for pregnancy success; TGF-β1 and TGF-β2 play important roles in regulating these processes. Pregnancy-specific β-glycoproteins (PSGs) are present in the maternal circulation at a high concentration throughout pregnancy and have been proposed to have anti-inflammatory function ...[more]

PMID: 23945545

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Dataset Information

Pregnancy-specific glycoprotein 1 (PSG1) activates TGF-? and prevents dextran sodium sulfate (DSS)-induced colitis in mice.

Publications

Pregnancy-specific glycoprotein 1 (PSG1) activates TGF-β and prevents dextran sodium sulfate (DSS)-induced colitis in mice.

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