Virus-mimetic cytoplasm-cleavable magnetic/silica nanoclusters for enhanced gene delivery to mesenchymal stem cells.
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ABSTRACT:
SUBMITTER: Gandra N
PROVIDER: S-EPMC3844676 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
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Virus-mimetic cytoplasm-cleavable magnetic/silica nanoclusters for enhanced gene delivery to mesenchymal stem cells.
Gandra Naveen N Wang Dong-Dong DD Zhu Ye Y Mao Chuanbin C
Angewandte Chemie (International ed. in English) 20130828 43
It does get in: Phage is made of DNA as a core and protein as a coat, and it can transfer DNA into host cells with high efficiency. Phage-mimetic gene transfer to hard-to-transfect mesenchymal stem cells (MSCs) was achieved using virus-mimetic magnetic silica nanoclusters (VMSNCs). The VMSNCs bear MSC-homing phage-borne protein on the surface and encapsulate DNA inside, promoting the transfer of DNA into MSCs. ...[more]
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