Ontology highlight
ABSTRACT:
SUBMITTER: Jakobsen MR
PROVIDER: S-EPMC3845190 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Jakobsen Martin R MR Bak Rasmus O RO Andersen Annika A Berg Randi K RK Jensen Søren B SB Tengchuan Jin J Laustsen Anders A Hansen Kathrine K Ostergaard Lars L Fitzgerald Katherine A KA Xiao T Sam TS Mikkelsen Jacob G JG Mogensen Trine H TH Paludan Søren R SR
Proceedings of the National Academy of Sciences of the United States of America 20131023 48
Replication of lentiviruses generates different DNA forms, including RNA:DNA hybrids, ssDNA, and dsDNA. Nucleic acids stimulate innate immune responses, and pattern recognition receptors detecting dsDNA have been identified. However, sensors for ssDNA have not been reported, and the ability of RNA:DNA hybrids to stimulate innate immune responses is controversial. Using ssDNAs derived from HIV-1 proviral DNA, we report that this DNA form potently induces the expression of IFNs in primary human ma ...[more]