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Plumeridoid C from the Amazonian traditional medicinal plant Himatanthus sucuuba.

ABSTRACT: The stereochemistry of the iridoid plumeridoid C, C(15)H(18)O(7), was established by X-ray single-crystal structure analysis, giving (2'R,3R,4R,4aS,7aR)-methyl 3-hydroxy-4'-[(S)-1-hydroxyethyl]-5'-oxo-3,4,4a,7a-tetrahydro-1H,5'H-spiro[cyclopenta[c]pyran-7,2'-furan]-4-carboxylate. The absolute structure of the title compound was determined on the basis of the Flack x parameter and Bayesian statistics on Bijvoet differences. The hydrogen-bond donor and acceptor functions of the two hydroxy groups are employed in the formation of O-H···O-bonded helical chains.

SUBMITTER: Waltenberger B

PROVIDER: S-EPMC3845386 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

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Plumeridoid C from the Amazonian traditional medicinal plant Himatanthus sucuuba.

Waltenberger Birgit B Rollinger Judith M JM Griesser Ulrich J UJ Stuppner Hermann H Gelbrich Thomas T

Acta crystallographica. Section C, Crystal structure communications 20110929 Pt 10

The stereochemistry of the iridoid plumeridoid C, C(15)H(18)O(7), was established by X-ray single-crystal structure analysis, giving (2'R,3R,4R,4aS,7aR)-methyl 3-hydroxy-4'-[(S)-1-hydroxyethyl]-5'-oxo-3,4,4a,7a-tetrahydro-1H,5'H-spiro[cyclopenta[c]pyran-7,2'-furan]-4-carboxylate. The absolute structure of the title compound was determined on the basis of the Flack x parameter and Bayesian statistics on Bijvoet differences. The hydrogen-bond donor and acceptor functions of the two hydroxy groups ...[more]

PMID: 21979978

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