Ontology highlight
ABSTRACT:
SUBMITTER: Peinado JR
PROVIDER: S-EPMC3845801 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Peinado Juan R JR Sami Furqan F Rajpurohit Nina N Lindberg Iris I
FEBS letters 20130913 21
The deposition of fibrillated human islet β-cell peptide islet amyloid polypeptide (hIAPP) into amyloid plaques is characteristic of the pathogenesis of islet cell death during type 2 diabetes. We investigated the effects of the neuroendocrine secretory proteins 7B2 and proSAAS on hIAPP fibrillation in vitro and on cytotoxicity. In vitro, 21-kDa 7B2 and proSAAS blocked hIAPP fibrillation. Structure-function studies showed that a central region within 21-kDa 7B2 is important in this effect and re ...[more]