A randomized controlled trial of high dose vitamin D3 in patients with heart failure.

ABSTRACT:

Objective

To investigate the effect of Vitamin D3 on physical performance in patients with HF.

Background

HF is associated with functional decline and frailty. Vitamin D deficiency is associated with loss of muscle strength and poor outcomes in patients with HF.

Methods

Sixty-four patients participated in a 6-month parallel design double blind RCT to test the hypothesis that oral vitamin D3 would improve physical performance. Vitamin D3 50,000 IU or placebo was given weekly; all received daily calcium. Patients were included regardless of EF and 25OHD ≤ 37.5 ng/ml. The primary outcome was peak VO2, and secondary outcomes were the 6MW, TGUG and knee isokinetic muscle strength. Between group comparisons were made using ANCOVA models that adjust for baseline measures.

SUBMITTER: Boxer RS 

PROVIDER: S-EPMC3845907 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature